Chemotherapy may cause diarrhoea, which may be associated with treatment delay and
infections. The purpose of the study is to investigate whether oral supplementation with
lactobacilli will alleviate chemotherapy related diarrhoea. Patients diagnosed with advanced
colorectal cancer and who will receive chemotherapy will be randomly assigned to receive
either lactobacilli or placebo during chemotherapy. The study is a prospective, multicenter,
randomized, double-blind, placebo-controlled study. The primary outcome measure is frequency
of moderate/severe diarrhoea. The study will also address safety and tolerability of
chemotherapy, response to chemotherapy, and serum growth factor levels.
Sep 30,2005
All
18 Years
N/A
18 Years
N/A
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