PerMiCCion

Colorectal cancer (CRC) stands as a global health challenge, affecting over 5 million individuals worldwide. At PerMiCCion, researchers are pioneering a transformative approach to understanding and combating CRC by exploring the gut microbiome (the ecosystem of microorganisms residing in the gastrointestinal tract).

The prevalence of CRC among young adults is rising, indicating an urgent need for innovative solutions. While genetic predispositions play a role, lifestyle factors such as diet, physical activity, and other habits significantly influence an individual’s susceptibility to this disease. PerMiCCion recognises the pivotal role of gut microbiota in shaping health outcomes.

PerMiCCion focuses on early-onset CRC, denoting CRC that manifests before age 50. While existing studies predominantly centre on CRC in older cohorts, statistics reveal a significant surge in incidence among younger demographics over recent decades. The mechanistic pathways leading to CRC in younger adults remain elusive, raising questions about the efficacy of treatments designed for this age group. Consequently, the research agenda is sharply pointed towards explaining these uncertainties, with the aim of furnishing invaluable insights into early-onset CRC and facilitating the development of tailored interventions.

The research at PerMiCCion is centred around three key objectives:

• Identifying Microbiome Markers: Researchers are studying the gut microbiota in CRC patients to unearth microbiome markers that could transform early diagnosis and monitoring of this disease.
• Exploring Healthy Gut Microbiota: Delving into the gut microbiota of healthy individuals with diverse dietary and lifestyle habits offers invaluable insights. Researchers aim to lay the groundwork for preventing the early onset of CRC by discerning which practices nurture a healthy gut microbiome.
• Personalised Interventions to improve Quality of Life: PerMiCCion aspires to offer personalised dietary and lifestyle recommendations. These tailored interventions aim to restore a healthy microbial gut ecosystem, ultimately enhancing the quality of life for individuals navigating CRC.

By unraveling the mysteries of the gut microbiome, PerMiCCion is paving the way for innovative approaches to CRC prevention, diagnosis, and treatment. Together, let’s embark on this journey toward a healthier tomorrow. Join PerMiCCion to help make a meaningful impact on the lives of those affected by CRC.

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