Advancing a Precision Medicine Paradigm in metastatic Colorectal Cancer: Systems based patient stratification solutions (COLOSSUS)

A DiCE Research Project


COLOSSUS aims to provide new and more effective ways to classify patients with a specific subtype of metastatic colorectal cancer (microsatellite stable RAS mutant metastatic colorectal cancer or MSS RAS mt mCRC) and to develop new treatment options for them. Our ultimate goal is to deliver a personalised medicine approach for patients with MSS RAS mt mCRC, that is currently not available.
The COLOSSUS consortium is studying patient and biobank samples and applying advanced multi-omic computational modelling approaches to identify new MSS RAS mt specific subtypes. This strategy is designed to help predict patient outcomes under standard treatment and to enable the design of more targeted and personalised regimens.

All project materials can be found here:
In addition to the explainer video, Project materials include the COLOSSUS brochure pdf, slide in English and Spanish, annual newsletters, a pull-up banner and our event flyers.

Project Brochure

Our Partners

  • Royal College of Surgeons in Ireland
  • Vall d’Hebron Institute of Oncology
  • University College Dublin
  • The Institute of Cancer Research
  • VIB
  • Ruprecht Karls-Universitaet Heidelberg
  • Universita Degli Studi di Torino
  • Irish Clinical Oncology Research Group CLG (Cancer Trials Ireland)
  • Optimata Ltd
  • GeneXplain GmbH
  • HalioDx
  • Epigenomics AG
  • Pintail Limited

Our Sponsors

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 754923. The material presented and views expressed here are the responsibility of the author(s) only. The EU Commission takes no responsibility for any use made of the information set out.

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