Colorectal Cancer (Bowel Cancer)
Early Onset Colorectal Cancer

About Early Onset CRC

About Early Onset CRC

While overall colorectal cancer (CRC) cases have declined since the mid-1980s, diagnoses are rising in people under the age of 50. CRC in the population younger than 50 years is defined as early-age onset or early-onset CRC. Adults born around 1950 versus around 1990, double their risk of colon cancer and quadruple their risk of rectal cancer; 11% of colon cancers and 23% of rectal cancers will occur in young individuals (<50 years) by 2030.1,2 However, the incidence of CRC worldwide has increased consistently in every age group of adults 20 to 54 years over the last two decades without an obvious cause.3


1. Siegel RL, Fedewa SA, Anderson WF, et al. Colorectal cancer incidence patterns in the United States, 1974–2013. J Natl Cancer Inst 2017; 109: 8.
2. Bailey CE, Hu CY, You YN, et al. Increasing disparities in the age-related incidences of colon and rectal cancers in the United States, 1975–2010. JAMA Surg 2015; 150: 17–22
3. Chang SH, Patel N, Du M, Liang PS. Trends in early-onset vs late-onset colorectal cancer incidence by race/ethnicity in the United States cancer statistics database. Clin Gastroenterol Hepatol 2021; published online July 26. https://doi.org/10.1016/ j.cgh.2021.07.035.

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