The American Society of Clinical Oncology (ASCO) Annual Meeting continues to be one of the most important events for cancer research, bringing together the latest advances from around the world. This year, DiCE closely followed the latest updates, including new findings that could improve outcomes and quality of life for people affected by colorectal cancer.

The CHALLENGE trial observed nearly 900 people with completely resected stage III or high-risk stage II colon cancer who had completed adjuvant chemotherapy. Participants either joined a three-year structured exercise programme with professional coaching and support or received standard health education materials.

Phase III of the CHALLENGE trial (CCTG CO.21), whose results were published during the 2025 ASCO Annual Meeting, has already shown that the exercise programme has major benefits, helping patients live longer and reducing the risk of cancer returning. Since the CHALLENGE trial results were published, the structured exercise program has been adopted into leading clinical practice guidelines, such as the ESMO and NCCN guidelines.

Researchers have now found that the programme may also reduce healthcare costs.

Although the exercise program required an upfront investment, participants needed less treatment for cancer recurrence and fewer cancer-related healthcare services. This led to total savings of approximately $1,589 per patient (in Canadian dollars), which corresponds to around €987. Additionally, patients in the exercise group experienced longer survival and reported higher quality of life, gaining nearly 0.10 quality-adjusted life years (QALYs) compared with those who received standard health education.

When researchers incorporated these benefits into a standard metric used in health economics, the program was shown to be highly cost-effective.

For people recovering from colon cancer, exercise can be an important part of treatment, helping them stay healthier for longer while potentially reducing the burden on healthcare systems.

As evidence continues to grow, structured exercise programmes may become a routine part of clinical cancer care.  As DiCE, we are committed to encouraging physical activity to help prevent digestive cancers and support healthy ageing. During our 11th Masterclass in Munich, we are hosting a Fun Run on 3 July 2026 in collaboration with Outdoor Against Cancer. Additionally, we will continue to advocate for healthy habits and regular exercise through upcoming awareness campaigns. Stay updated by visiting our website and social media to follow our efforts in this area.

Author:

Luca Arfini